Title: Pediatric liver transplant pathology: an update and practical consideration
Source: Surgical Pathology Clinics 2025, 18 (2): 371-382
Date of publication: June 2025
Publication type: Review article
Abstract: This review provides a summary of the diagnostic approach to pediatric liver transplantation (LT) pathology. It emphasizes the pathologic features of T-cell-mediated rejection, the most common finding on liver allograft biopsies, and discusses other forms of rejection, including the less frequent antibody-mediated rejection. The article incorporates insights from the recently published Banff 2022 Liver Group Meeting Report. Additionally, it covers other complications such as biliary and vascular issues, infections, and disease recurrence. Finally, the review summarizes the potential applications of novel technologies, including next-generation pathology and artificial intelligence, in the context of pediatric LT pathology.
