Title: Determinants of early surgical complications after pediatric liver transplantation: a single center/single surgeon experience over 20 years
Source: Clinics and Research in Hepatology and Gastroenterology 2023, Sep 30. [E–publication]
Date of publication: September 2023
Publication type: Article
Abstract: Background: The risk of early surgical complications of liver transplantation (LT) is higher in children when compared with adults. The aims of the present retrospective study from a single center cohort/single surgeon were to identify the predictive factors for surgical complications after pediatric LT.
Methods: All children receiving a first LT from October 1990 to October 2010 in our center were included.
Results: Included 151 children (boys 55.0%), with a mean age of 4.8±4.8 years, and a mean weight of 17.9±14.4 kg. Thirty-seven patients were transplanted within the first year, and 59 patients had a body weight below 10 kg. The main initial liver disease was biliary atresia (49.0%). Living donor LT was performed in 39 cases (25.8%), cadaveric whole liver LT in 50 cases (33.1%), and cadaveric partial liver LT in 62 cases (41.1%). Early surgical complications included reoperation (37.8%), vascular complications (8.6%), i.e. arterial (3.3%) or portal thrombosis/stenosis (7.3%) within the first month, and biliary complications in the first 90 days occurred in 22.5% of the cases. The main indications for surgical revision were abdominal bleeding, treatment of a biliary complication, and bowel perforation. Multivariate analysis disclosed that only graft type (split and moreover from a living donor) was significantly and independently associated with the occurrence of biliary complication, and that indication for LT, period, graft type, and operative time were significantly and independently associated with the necessity of surgical revision.
Conclusion: Our results emphasize that surgical complications are frequent and strongly depend on patient/graft characteristics.